Upon irradiation with nm visible light the irreversible photolytic reaction produced raseglurant. The following figure supplements are available for Figure 1. A Determination of mGlu 5 receptor-mediated inositol phosphate accumulation in transiently transfected HEKT cells. The pEC 50 value determined for quisqualate was 7. C Quantification of mGlu 5 receptor inhibition. D Expression of mGlu 5 receptor in primary striatal neurons.
A large number of behavioural methods have been developed to investigate nociception and the actions of analgesic drugs in animals. The formalin test is increasingly used as a model of injury-produced pain. The generally accepted method of rating pain used for mice is to count or time paw licks. The aim of this study was to examine scoring properties of other behaviours in the formalin test in mice, and determine the best measure of pain.
A nociception assay nocioception or nocioperception assay evaluates the ability of an animal, usually a rodent, to detect a noxious stimulus such as the feeling of pain, caused by stimulation of nociceptors. These assays measure the existence of pain through behaviors such as withdrawal, licking, immobility, and vocalization. The sensation of pain is not a unitary concept; therefore, a researcher must be conscious as to which nociception assay to use.